(±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 µM) from rat basophilic leukemia cells. The lactone form is several times more potent.
R11 - Highly flammable R38 - Irritating to skin R48/20 - Harmful: danger of serious damage to health by prolonged exposure through inhalation R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment R62 - Possible risk of impaired fertility R65 - Harmful: may cause lung damage if swallowed R67 - Vapours may cause drowsiness and dizziness
Safety Codes:
S16 - Keep away from sources of ignition - No smoking S29 - Do not empty into drains S33 - Take precautionary measures against static discharges S36/37 - Wear suitable protective clothing and gloves S61 - Avoid release to the environment. Refer to special instructions/safety data sheet S62 - If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible S9 - Keep container in a well-ventilated place
Hazard Symbols:
F, Xn, N
Storage temperature :
-20 °C
x
Alternative Distributors of [(±) 5-HETE Lactone]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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