Hydroxyfasudil Hydrochloride | CAS 155558-32-0

Element: hydroxyfasudil hydrochloride

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C-S » Chemicals » hydroxyfasudil-hydrochloride-PX73345

Identification

Hydroxyfasudil Hydrochloride

CAS:

155558-32-0

EINECS:

Molecular Formula:

C₁₄H₁₇ N₃ O₃ S . Cl H

MDL:

MFCD06411567

SMILES:

Cl.OC1=NC=CC2=C(C=CC=C12)S(=O)(=O)N1CCCNCC1

Synonym:

hydroxyfasudil hydrochloride ; hydroxyfasudil monohydrochloride ; hydroxyfasudil hydrochloride hydrate ; 5-[(hexahydro-1h-1,4-diazepin-1-yl)sulfonyl]-1(2h)-isoquinolinone ; 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine monohydrochloride ; 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate ; hydroxyfasudil hydrochloride hydrate,1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride hydrate ; 1h-1,4-diazepine,1-[(1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-, monohydrochloride(9ci) ; 1-(1-hydroxy-5-isoquinolinesulfonyl)homopiperazine hydrochloride ; 1(2h)-isoquinolinone,5-[(hexahydro-1h-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:1)

Description

Hydroxyfasudil hydrochloride is a cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rock (Rho-kinase) (IC₅₀ = 0.9 and 1.8 μM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKb, and PKC. Hydroxyfasudil hydrochloride is reported to inhibit the Rock (Rho kinase)-mediated contraction in vitro.

Suppliers

Finetech Industry Limited

FIL14005600

BOC Sciences

BS6722016

Amadis Chemical Company Limited

ACCL17368680

Santa Cruz Biotechnology, Inc.

202176

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CAS equal suppliers

Hydroxyfasudil HCl

CSNpharm, Inc.

CSN15927

Prices & Availability

Data is processed

Properties for Hydroxyfasudil Hydrochloride

Molecular Weight:

343.82902 g·mol−1

Melting point:

>250 (dec.)

Boiling point:

622.8° C at 760 mmHg (Predicted) (tautomer)

Solubility:

Soluble in aqueous acid, methanol (sparingly), and water (20 mM).

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed

Hazard Symbols:

Storage temperature :

2-8°C

Alternative Distributors of [Hydroxyfasudil Hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Suzhou Rovathin Pharmatech Co., Ltd | Clearsynth Canada INC.

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