N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester | CAS 615264-52-3

Element: hydroxyphenyl phenylalanine propenyl methyl ester

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Identification

N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester

CAS:

615264-52-3

EINECS:

Molecular Formula:

C₁₉H₁₉NO₄

MDL:

MFCD08062178

SMILES:

COC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C=CC2=CC=C(C=C2)O

Synonym:

cay10486 ; n-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-l-phenylalanine, methyl ester ; 4-hydroxycinnamic acid (l-phenylalanine methyl ester) amide

Description

N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, inhibits human Acyl-Coenzyme A cyltransferase-1 and -2 (ACAT-1 and ACAT-2) equally (IC₅₀ ~ 60 μM). ACAT-1 and ACAT-2 catalyze the formation of long chain fatty acyl-coenzyme A and cholesterol esters from cholesterol, and may play a role in the development of atherosclerosis. Additionally, at a concentration of 3μM, N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester, demonstrates ~28% inhibition of copper-mediated oxidation of low density lipoproteins.

Suppliers

Santa Cruz Biotechnology, Inc.

221976

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CAS equal suppliers

N-[3-(4-Hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine methyl ester

Dayang Chem (Hangzhou) Co.,Ltd.

DC1925177004

Prices & Availability

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Properties for N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester

Molecular Weight:

325.36 g·mol−1

Density:

~1.2 g/cm³ (Predicted)

Melting point:

215.26° C (Predicted)

Boiling point:

~577.3° C at 760 mmHg (Predicted)

Solubility:

Soluble in ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), DMSO: PBS (1: 5, pH 7.2) (~0.5 mg/ml), and water (0.5 mg/ml at 25.0° C).

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Alternative Distributors of [N-[3-(4-hydroxyphenyl)-1-oxo-2-propenyl]-L-phenylalanine, methyl ester]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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