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Imatinib mesylate

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Formula: C29H31N7O.CH4O3S
CAS: 220127-57-1
search Element: imatinib mesylate
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Identification

Structural Formula
Imatinib mesylate
CAS:
220127-57-1
EINECS:
Molecular Formula:
C29H31N7O.CH4O3S
MDL:
MFCD04307699
SMILES:
CS(O)(=O)=O.CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC=C(C)C(NC3=NC=CC(=N3)C3=CC=CN=C3)=C2)CC1
Synonym:
tinib mesylate ; genfatinib ; gleevec ; st-1571 mesylate ; cgp54148b ; glivec ; cgp 57148 ; gleevac ; cgp-57148b ; sti-571


Description

Imatinib mesylate is a small molecule that inhibits the c-Abl protein-tyrosine kinase, a kinase specifically important for proliferation of chronic myelogenous leukemia (CML). A translocation event between chromosomes 9 and 22 generates the Philadelphia chromosome, which then produces the Bcr-Abl fusion protein with aberrant kinase activity that promotes rapid cell proliferation. Imatinib binds up this crucial kinase, halting CML related growth. Imatinib mesylate has further been displayed to inhibit PDGFR and tyrosine kinases associated with c-Kit.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
I0002.00
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI23469384
+
Shandong Minglang Chemical Co., Ltd
SMC11904760
+
H&Z Industry Co.,Ltd
HIC6802720
+
Ambeed, Inc.
A265691
+
Shandong SanYoung Industry Co., Ltd
SSI11904760
+
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT17348670
+
Arcadia Biotechnology
AB7142142
+
Xiamen Equation Chemical Co.,Ltd
XECC10885440
+
Sancai Industry Co.,Ltd.
SIC8163264
+
Aecochem Corp.
AC4761428
+
CSNpharm, Inc.
CSN16807
Finetech Industry Limited
FIL8503400
+
Carbone Scientific Co., Ltd.
CS9522856
+
AK Scientific, Inc.
AS6461938
+
Simagchem Corporation
SC7142142
+
Xingrui Industry Co., Limited
XIL9863944
+
Capot Chemical Co., Ltd.
18211
+
BOC Sciences
BS4081224
+
Amadis Chemical Company Limited
ACCL10545270
+
Santa Cruz Biotechnology, Inc.
202180
Dayang Chem (Hangzhou) Co.,Ltd.
DC10544216
+
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Prices & Availability




Data is processed


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Properties for Imatinib mesylate

Molecular Weight:
589.71 g·mol−1
Melting point:
214-224°C
Solubility:
Soluble in water (200 mg/ml), ethanol (~0.2 mg/ml), DMSO (200 mg/ml), DMF (~10 mg/ml), and methanol (sparingly).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
-20°C Freezer
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Alternative Distributors of [Imatinib mesylate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Yore Chemipharm Co., Limited | Qventas, Inc. | Hangzhou Onicon Chemical Co., Ltd. | Benro Internatinal Co., Linc | CCS. CHEM. Co., Ltd. | Xiang Ding Chemical International Co., Ltd | Shanghai PI Chemicals Ltd. | Qichun QiLong Chemical Co., Ltd. | Shanghai Me-too Pharma Tech Co., Ltd. | Pharmasi Chemicals Co., Ltd. | Taizhou Bolon Pharmachem Co.,Ltd.. / Bolon Pharm & Chem Co., Ltd. | Shanghai Henghe Pharma-Tech Co., Ltd. | Jiangxi Sanpharm Fine Chemical Co., Ltd. | Genatal Life Science Ltd. | Nanjing Ange Pharmaceutical Co., Ltd. | Melone Pharmaceutical Co., Ltd. | Zhejiang Esun Chemical Co., Ltd. | Ningbo Inno Pharmchem Co. Ltd. | Conier Chem & Pharma Ltd | ShangHai Biochempartner Co., Ltd. | Zibo Panxin Pharmaceutical Co., Ltd. | ZhiYu Biotechnology Co., Ltd. | China Risesun Group Co., Ltd. | Shanghai Yongyi Biotechnology Co., Ltd. | Discovery Fine Chemicals Limited | Hangzhou Sida Organic Chemical Co., Ltd. | Jinan Wedo Industrial Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Yingxuan Chempharm Co., Ltd. | Shanghai AOKChem Group Limited | JingZhou WinChem Pharm.&Chem. Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Richem International Co., Ltd. | Chemrio International Limited | Share Chemical Co., Ltd. | TRUST&WE Co., Ltd. | Kinfon Pharmaceutical and Chemical Service Co., Ltd. | Wuxi Mizat Chemical Technology Co., Ltd. | Shanghai ChemVia Co., Ltd | Shanghai Marketing Center of Yangzhou Princechem Co., Ltd. | Hangzhou Pharma & Chem Co. Ltd. | Lanospharma Laboratories Co., Ltd. | Lianyungang Sheng He Biotechnology Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | ForeChem Ltd. | Jinan Great Chemical Co., Ltd. | Bichem Lab Co., Ltd. | Hangzhou Xiaoshan Jiangchen Chemicals Co., Ltd. | Shanghai Insight Chemicals Co., Ltd. | Hangzhou Holypharm Biotech Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Taizhou Creating Chemical Co., Ltd. | All Right Chemical Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Pharmfar Co., Ltd. | Watson International Ltd | Aopharm | Shanghai Arbor Chemical Co., Ltd. | BOC Sciences | Wolves R&D Chemicals | Jinan Haohua Industry Co., Ltd. | Finetech Industry Limited | Xiamen Hisunny Chemical Co., Ltd. | Sino Rarechem Labs Co. Ltd. | Clearsynth Canada INC. | Angel Synthesis Co., Ltd | Agilebiochem Co., Ltd | Wanko Chemical Co., Ltd. | Haihang Industry Co., Ltd.

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