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Indirubin-3'-monoxime

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Formula: C16H11N3O2
CAS: 160807-49-8
search Element: indirubin monoxime
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Identification

Structural Formula
Indirubin-3'-monoxime
CAS:
160807-49-8
EINECS:
Molecular Formula:
C16H11N3O2
MDL:
MFCD02683594
SMILES:
C1=CC=C2C(=C1)C(=C(N2)C3=C4C=CC=CC4=NC3=O)NO
Synonym:
3-[1,3-dihydro-3-(hydroxyimino)-2h-indol-2-ylidene]-1,3-dihydro-2h-indol-2-one ; indirubin-3'-monoxime ; indirubin-3'-oxime ; indirubine-3'-oxime ; indirubin-3'-monooxime ; indirubin-3'


Description

Indirubin-3'-monoxime is a potent inhibitor of GSK-3β (IC50=22 nM)1. Indirubin-3'-monoxime also inhibits CDK1 (p34cdc2; IC50=180 nM) and CDK5 (IC50=100 nM)1. Indirubin-3'-monoxime reversibly arrests asynchronous HBL-100 cells at G22. This compound induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM). Indirubin-3'-monoxime is an inhibitor of Cdk2, cyclin A, cyclin B, cyclin E and p35.


Suppliers

Amadis Chemical Company Limited
ACCL13026510
+
Santa Cruz Biotechnology, Inc.
202660
Dayang Chem (Hangzhou) Co.,Ltd.
DC13025208
+
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CAS equal suppliers

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Prices & Availability




Data is processed


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Properties for Indirubin-3'-monoxime

Molecular Weight:
277.28 g·mol−1
Density:
1.50
Melting point:
247-249 °C
Boiling point:
645.5° C at 760 mmHg (Predicted)
Solubility:
DMSO: >10 mg/mL
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Safety & Transport Information

Storage temperature :
Store at RT
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Alternative Distributors of [Indirubin-3'-monoxime]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Gihi Chemicals Co., Limited | Jinan Haohua Industry Co., Ltd.

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