JNJ 10191584 maleate | CAS 869497-75-6

Element: 10191584 maleate

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » jnj-maleate-PX73135

Identification

JNJ 10191584 maleate

CAS:

869497-75-6

EINECS:

Molecular Formula:

C₁₃H₁₅ClN₄O.C₄H₄O₄

MDL:

MFCD09878266

SMILES:

CN1CCN(CC1)C(=O)C2=NC3=C(N2)C=C(C=C3)Cl.C(=CC(=O)O)C(=O)O

Synonym:

1-[(5-chloro-1h-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate ; vuf 6002 ; vuf 6002 maleate ; vuf6002 maleate ; jnj 10191584 maleate salt ; jnj 10191584 maleate

Description

JNJ 10191584 maleate is a highly selective Histamine H₄ Receptor silent antagonist that binds with high affinity to the human H₄ receptor (K_i = 26 nM). This compound is > 540-fold selective over the H₃ receptor (K_i = 14.1 μM). In vitro,J NJ 10191584 maleate inhibits mast cell and eosinophil chemotaxis with IC₅₀ values of 138 and 530 nM, respectively.