Juglone | CAS 481-39-0 | Chemical-Suppliers

Element: juglone

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C-S » Chemicals » juglone-PX70609

Identification

Juglone

CAS:

481-39-0

EINECS:

207-567-5

Molecular Formula:

C₁₀H₆O₃

MDL:

MFCD00001684

SMILES:

C1=CC2=C(C(=O)C=CC2=O)C(=C1)O

Synonym:

nucin ; akhnot ; iuglon ; juglon ; yuglon ; juglane ; jugnlon ; juglone ; nci 2323 ; regianin

Description

Juglone inhibits the transcription of Pol II (RNA polymerase II) by changing the sulfhydryl groups and blocking the assembly of the preinitiation complex. Other studies show that Juglone does not block T7 RNA polymerase but that it inhibits Pol II and Pol III (RNA polymerase II and III). Human Pin1, Escherichia coli parvulin, and the yeast Ess1/Ptf1 have been shown to be blocked specifically and irreversibly by Juglone. Additionally, Juglone is an antifibrotic compound and promotes apoptosis via the mitochondrial-dependent pathway. Juglone is an inhibitor of Cyclophilin and Pin4.

Suppliers

Chengdu Pufeide Biotech. Co., Ltd

CPB231924

Indofine Chemical Co, Inc.

020425

JieJie Group Co., Ltd.

JG154462

Xiamen Equation Chemical Co.,Ltd

XECC2241120

CM Fine Chemicals

CFC119476

Santa Cruz Biotechnology, Inc.

202675

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Prices & Availability

Data is processed

Properties for Juglone

Molecular Weight:

174.15 g·mol−1

Density:

~1.4 g/cm³ (Predicted)

Melting point:

161-163 °C(lit.)

Boiling point:

~385.83° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (10 mg/ml), ethanol (10 mg/ml), benzene (Freely soluble), chloroform (Freely soluble), ether, aqueous solution of alkalies, and hot water.

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS09
Environmental hazard

Acute hazards to the aquatic environment, category 1
Chronic hazards to the aquatic environment, categories 1, 2
Environmental toxicity, categories 1, 2

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1

Hazard Symbols:

Storage temperature :

Refrigerator (+4°C)

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Juglone]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Ubichem PLC | Carl Roth GmbH + Co KG | Shanghai Witofly Chemical Co., Ltd.

Downloads

Mol File:

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MSDS:

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