Ketoconazole | CAS 65277-42-1 | Chemical-Suppliers

Element: ketoconazole

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C-S » Chemicals » ketoconazole-PX79691

Identification

Ketoconazole

CAS:

65277-42-1

EINECS:

265-667-4

Molecular Formula:

C₂₆H₂₈Cl₂N₄O₄

MDL:

MFCD00058579

SMILES:

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OC[C@H]3CO[C@](O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Synonym:

onofin k ; nizral ; fungoral ; nizoral ; fungarest ; kw-1414 ; brizoral ; r-41400 ; fitonal ; ketoderm

Description

Ketoconazole is an imidazole-containing small molecule inhibitor of cytochrome P-450-dependent steps in the biosynthesis of steroid hormones; also inhibits TXA Synthase (thromboxane synthetase) and 5-LO (5-lipoxygenase) activity. Ketoconazole exhibits antimetastatic, antineoplastic, and antipsoriatic activity. Inhibition of 5-LO (5-lipoxygenase) by Ketoconazole interrupts arachidonic acid-derived leukotriene production, which was correlated to a suppression of leukotriene-mediated anaphylactic bronchoconstriction in guinea pigs. Ketoconazole is described as reducing platelet cellular levels of thromboxane A₂, suppressing thromboxane A₂-mediated increase of microvascular permeability in response to ischemia insults. Ketoconazole produces an antiandrogen effect through inhibition of adrenocorticoid biosynthesis, suppressing the adrenal secretion of androgens and attenuating cortisol response. Ketoconazole is an inhibitor of CYP17A1, CYP3A4 and CYP3A5.

Suppliers

Shandong Minglang Chemical Co., Ltd

SMC4201680

R&D Scientific Inc.

RS228684

Shandong SanYoung Industry Co., Ltd

SSI4201680

Ambeed, Inc.

A183059

H&Z Industry Co.,Ltd

HIC240960

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI8283312

Gyma Laboratories Of America, Inc.

GLOA4082040

Fabrichem, Inc.

F180360

CellMark AB

CA132396

AXO Industry SA

AIS180720

X´ian Taicheng Chem Co., Ltd

XTC3481392

Caesar & Loretz GmbH

CL240720

Sancai Industry Co.,Ltd.

SIC2881152

Aecochem Corp.

AC168504

CSNpharm, Inc.

CSN16776

Hangzhou Keying Chem Co., Ltd.

HKC3601440

Wanko Chemical Co., Ltd.

WC288864

Sigma-Aldrich International GmbH

SI3841152

scienTEST - bioKEMIX GmbH

S-B3001200

Finetech Industry Limited

FIL3001200

Carbone Scientific Co., Ltd.

CS3361008

Hefei Hirisun Pharmatech Co., Ltd

HR010485

AK Scientific, Inc.

AS228684

Simagchem Corporation

SC252756

Xingrui Industry Co., Limited

XIL3481392

BOC Sciences

BS144432

Leap Chem Co., Ltd

LC216648

Santa Cruz Biotechnology, Inc.

200496

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

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CAS equal suppliers

Ketoconazole, 98%

Alfa (A Johnson Matthey Company)

A5441632

Ketoconazole, Pharma

Xiamen Equation Chemical Co.,Ltd

XECC12806400

cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H)-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine

Chemos GmbH & Co. KG

CC38760116280

(+/-)-cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

Manchester Organics Limited

P25350

cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolane-4-yl]methoxyl]phenyl]piperazine

BLD Pharmatech Ltd

BP33408100224

Prices & Availability

Data is processed

Properties for Ketoconazole

Molecular Weight:

531.43 g·mol−1

Density:

~1.4 g/cm³ (Predicted)

Melting point:

146°C

Boiling point:

~753.4° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (20 mg/mL warm), ethanol (20 mg/mL warm), chloroform, water (<1 mg/mL), and methanol.

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

GHS09
Environmental hazard

Acute hazards to the aquatic environment, category 1
Chronic hazards to the aquatic environment, categories 1, 2
Environmental toxicity, categories 1, 2

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
R48/22 - Harmful: danger of serious damage to health by prolonged exposure if swallowed
R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
R60 - May impair fertility

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
S60 - This material and its container must be disposed of as hazardous waste
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
S7 - Keep container tightly closed

Hazard Classes:

6.1(b)

Hazard Symbols:

T, N, F

Storage temperature :

2-8°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Ketoconazole]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified