MAFP | CAS 188404-10-6 | Chemical-Suppliers

Element: mafp

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C-S » Chemicals » mafp-PX75496

Identification

MAFP

CAS:

188404-10-6

EINECS:

Molecular Formula:

C₂₁H₃₆FO₂P

MDL:

MFCD03095722

SMILES:

CCCCC/C=CC/C=CC/C=CC/C=CCCCCP(=O)(OC)F

Synonym:

mapf, phosphonofluoridic acid, methyl-5z,8z,11z,14z-eicosatetraenyl ester ; methylphosphonofluoridic acid 5,8,11,14-eicosatetraenyl ester ; phosphonofluoridic acid, methyl-5z,8z,11z,14z-eicosatetraenyl ester ; mapf ; mafp ; 5z,8z,11z,14z-eicosatetraenyl-phosphonofluoridic acid, methyl ester ; (all-z)-5,8,11,14-eicosatetraenylphosphonofluoridic acid methyl ester ; methyl arachidonyl fluorophosphonate ; phosphonofluoridicacid ; (5z,8z,11z,14z)-5,8,11,14-eicosatetraenylmethylester

Description

MAFP (methyl-arachidonoyl-fluoro-phosphonate) is an irreversible inhibitor of cPLA₂. Research has shown that this compound is also one of the most potent of the FAAH (anandamide amidohydrolase; Fatty acid amide hydrolase) inhibitors. Further studies suggest that MAFP completely blocks FAAH enzyme activity, the enzyme responsible for hydrolysis of endogenous cannabinoid ligand anandamide. Mechanistic studies suggest that this reagent specifically targets and phosphorylates arachidonyl binding sites. MAFP is an inhibitor of AChE. MAFP is an inhibitor of CB1. MAFP is an inhibitor of group VI iPLA2.

Suppliers

Santa Cruz Biotechnology, Inc.

203440

Dayang Chem (Hangzhou) Co.,Ltd.

DC124496

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CAS equal suppliers

Methyl arachidonyl fluorophosphonate, 98%

Alfa (A Johnson Matthey Company)

A393611808

Prices & Availability

Data is processed

Properties for MAFP

Molecular Weight:

370.48 g·mol−1

Density:

~1.0 g/mL (Predicted)

Melting point:

84.80° C (Predicted)

Boiling point:

~455.29° C at 760 mmHg (Predicted)

Flash point:

-16 °C

Solubility:

Soluble in methyl acetate, 100% ethanol (50 mg/ml), DMSO (50 mg/ml), DMF (~3 mg/ml), and 1:1 solution of ethanol: PES(pH7.2) (~0.5 mg/ml).

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36 - Irritating to eyes
R66 - Repeated exposure may cause skin dryness or cracking
R67 - Vapours may cause drowsiness and dizziness

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S29 - Do not empty into drains
S33 - Take precautionary measures against static discharges

Hazard Symbols:

F, Xi

Storage temperature :

-70°C

RID/ADR certification :

UN 1231 3 / PG 2

Alternative Distributors of [MAFP]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

Downloads

Mol File:

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MSDS:

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