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KB-R7943 MESYLATE

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Formula: C16H17N3O3S.CH3SO3H
CAS: 182004-65-5
search Element: mesylate r7943

Identification

Structural Formula
KB-R7943 MESYLATE
CAS:
182004-65-5
EINECS:
Molecular Formula:
C16H17N3O3S.CH3SO3H
MDL:
MFCD00952138
SMILES:
CS(=O)(=O)O.C1=CC(=CC=C1CCSC(=N)N)OCC2=CC=C(C=C2)[N+](=O)[O-]
Synonym:
2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea mesylate ; kb-r7943 ; kb-r7943 mesylate ; carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester methanesulfonate ; carbamimidothioic acid 2-[4-[(4-nitrophenyl)methoxy]phenyl]ethyl ester monomethanesulfonate ; 4-((4-nitrobenzyl)oxy)phenethyl carbamimidothioate methanesulfonate ; s-[4-[(4-nitrobenzyl)oxy]phenethyl]isothiourea methanesulfonate ; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate


Description

KB-R7943 mesylate is a cell permeable, potent, selective NCKX inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1. NCX1 is a Na+/Ca2+ exchanger predominantly expressed in cardiac sarcolemma, as well as in brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. NCX1 expression is up-regualted in human heart failure, as well as in other animal heart failure models. KB-R7943 reversibly inhibits inward and outward Na+/Ca2+ exchange in a dose-dependent manner, although it inhibits outward exchange more potently. Non-competitive with respect to Na+/Ca2+ and exhibits neuroprotection against glutamate excitotoxicity in rat cultured cerebellar granule neurons. KB-R7943 suppressed ventricular arrhythmias (tachycardia and fibrillation) associated with both ischemia and reperfusion almost completely in a rabbit ischemia-reperfusion model of cardiac injury. KB-R7943 is also a potent blocker of the transient receptor potential channels (TRPC) TRPC3, TRPC5 and TRPC6. KB-R7943 MESYLATE is an inhibitor of NCX1, NCX2, NCX3 and CCDC109.


Suppliers

CSNpharm, Inc.
CSN12367
Leap Chem Co., Ltd
LC6121836
Santa Cruz Biotechnology, Inc.
202681
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Prices & Availability




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Properties for KB-R7943 MESYLATE

Molecular Weight:
427.5 g·mol−1
Solubility:
Soluble in water (4 mg/mL ), and DMSO (40 mg/mL ).
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Safety & Transport Information

Storage temperature :
Store at RT
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Alternative Distributors of [KB-R7943 MESYLATE]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Taizhou Taifeng Chemical Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd

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