Methotrexate-methyl-d3 is a deuterated form of methotrexate, an antineoplastic and antirheumatic agent. Studies indicate that methotrexate-methyl-d3 can act as a folic acid antagonist. Methotrexate competitively and irreversibly inhibits dihydrofolate reductase (DHFR) which is essential in tetrahydrofolate synthesis. In addition, the reduction in tetrahydrofolate synthesis causes a decrease in purine base synthesis which results in the inhibition of DNA, RNA, thymidylates, and proteins. Alternate studies suggest that methotrexate-methyl-d3 can suppress T cell activation and adhesion molecule expression through IL-1 suppression.
R11 - Highly flammable R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed
Safety Codes:
S16 - Keep away from sources of ignition - No smoking S36/37 - Wear suitable protective clothing and gloves S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) S7 - Keep container tightly closed
Hazard Symbols:
F, T
Storage temperature :
-20 °C Freezer
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Alternative Distributors of [Methotrexate-methyl-d3]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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