Methotrexate trihydrate | CAS 133073-73-1

Element: methotrexate trihydrate

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C-S » Chemicals » methotrexate-trihydrate-PX74391

Identification

Methotrexate trihydrate

CAS:

133073-73-1

EINECS:

Molecular Formula:

C₂₀H₂₂N₈O₅

MDL:

MFCD00150847

SMILES:

CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.O.O.O

Synonym:

l-(+)-amethopterin hydrate ; l-amethopterin hydrate ; (+)-amethopterin hydrate ; l-mtx ; methylaminopterin hydrate ; antifolan hydrate ; methotrexate hydrate ; (+)amethopterine hydrate ; mtx hydrate ; methotrexate trihydrate

Description

Methotrexate trihydrate is the hydrated form of Methotrexate. Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G₁/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR. Methotrexate has also been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. Methotrexate was also noted to decrease IL-1 production in adherent splenic cells. Additionally offered as, Methotrexate.

Suppliers

Santa Cruz Biotechnology, Inc.

215309

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Data is processed

Properties for Methotrexate trihydrate

Molecular Weight:

454.44 g·mol−1

Melting point:

195 °C

Solubility:

H₂O: insoluble

Physical Description:

yellow to orange crystalline powder

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed
R36/38 - Irritating to eyes and skin
R46 - May cause inheritable genetic damage
R61 - May cause harm to the unborn child

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Symbols:

Storage temperature :

-20°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Methotrexate trihydrate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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