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6-Methoxy-2-Naphthylacetic acid

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Formula: C13H12 O3
CAS: 23981-47-7

Identification

Structural Formula
6-Methoxy-2-Naphthylacetic acid
CAS:
23981-47-7
EINECS:
245-967-1
Molecular Formula:
C13H12 O3
MDL:
MFCD00033105
SMILES:
COC1=CC2=C(C=C1)C=C(C=C2)CC(=O)O
Synonym:
2-naphthaleneaceticacid, 6-methoxy- ; desmethyl naproxen ; desmethyl naproxe ; brl 10720 ; 6-methoxy-2-naphthylacetic acid ; 6-methoxy naphthalene acetic acid ; 6-methoxy-2-naphthaleneacetic acid ; brl10720 ; 6-mna ; 6-metossi-2-naphtilacetico ; 6-methoxynaphthalene-2-acetic acid ; 2-(6-methoxy-2-naphthyl)aceticacid ; 6-methoxy-2-naphthaleneaceticaci ; 2-(6-methoxy-2-naphthyl)acetic acid


Description

6-Methoxy-2-Naphthylacetic acid is a competitive inhibitor of Cox (cyclooxygenase). 6-Methoxy-2-Naphthylacetic acid is selective for Cox-2 (IC50 = 15-55 μM) over Cox-1 (IC50 = 200-280 μM). 6-Methoxy-2-Naphthylacetic acid is a metabolite of Nabumetone with potential analgesic and anti-inflammatory effects. 6-Methoxy-2-Naphthylacetic acid has been shown to alter the pharmacokinetics and brain accumulation of IMP in monkeys. 6-Methoxy-2-Naphthylacetic acid was able to decrease reactive oxygen species creation in polymorphonuclear leukocytes. Evidence points out that 6-Methoxy-2-Naphthylacetic acid is phototoxic in vitro.


Suppliers

DSL Chemicals (Shanghai) Co., Ltd.
DC316212648
Santa Cruz Biotechnology, Inc.
200602
Dayang Chem (Hangzhou) Co.,Ltd.
DC288311532
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CAS equal suppliers

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Ambeed, Inc.
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BLD Pharmatech Ltd
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Prices & Availability




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Properties for 6-Methoxy-2-Naphthylacetic acid

Molecular Weight:
216.2326 g·mol−1
Density:
1.235 g/cm3
Melting point:
171-173°C
Boiling point:
408.8 °C at 760 mmHg
Flash point:
160.7 °C
Solubility:
Soluble in DMSO (25 mg/mL) and ethanol (10 mg/mL warm)
Physical Description:
off-white solid
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R37/38 - Irritating to respiratory system and skin
R41 - Risk of serious damage to eyes
R50 - Very toxic to aquatic organisms
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S39 - Wear eye/face protection
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet
Hazard Symbols:
Xn, Xi, N
Hazard symbol N Hazard symbol Xn Hazard symbol Xi
Storage temperature :
Refrigerator
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Alternative Distributors of [6-Methoxy-2-Naphthylacetic acid]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Synfine Research Inc. | Annker Organics Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Gihi Chemicals Co., Limited | Clearsynth Canada INC.

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