Mibefradil dihydrochloride

Mibefradil dihydrochloride is a nondihydropyridine antagonist and calcium channel protein inhibitor which selectively blocks Ca²⁺ entry into cells by inhibiting T-type (low-voltage activated) Ca²⁺ channels. In addition, it has been reported that mibefradil dihydrochloride can partially inhibit L-type (high-voltage activated) Ca²⁺ channels. Studies show that when this compound is combined with nisoldipine, an L-type Ca²⁺ antagonist, all calcium channels are completely blocked. Furthermore, in vitro studies indicate that mibefradil dihydrochloride protect CA1 neurons from delayed death after global ischemia in rats.