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Montelukast Sodium

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Formula: C35H35ClNNaO3S
CAS: 151767-02-1
search Element: montelukast sodium
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Identification

Structural Formula
Montelukast Sodium
CAS:
151767-02-1
EINECS:
Molecular Formula:
C35H35ClNNaO3S
MDL:
MFCD00931431
SMILES:
CC(C)(C1=CC=CC=C1CC[C@H](C2=CC=CC(=C2)/C=C/C3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)[O-])O.[Na+]
Synonym:
montelukast sodium ; montelukst sodium ; mk-0476 ; motelukast sodium ; mk-476-d6 ; mk-476 ; montelukast soudium ; mk-476, singulair ; singulair ; montelukast na


Description

Montelukast Sodium is a potent, selective, anti-inflammatory CysLT1 receptor antagonist (IC50 < 5nM) with no appreciable affect on the CysLT2 receptor. In rat colitis Montelukast Sodium has demonstrated the ability to increase PGE2 (Prostaglandin E2 - sc-201225) production and lower COX-2 expression. Inhibition is competitive with respect to leukotrienes - particularly LTD4, a biologically active mediator that plays an important role in the control of several biochemical pathways involving pulmonary and immune system function.


Suppliers

Ambeed, Inc.
A232574
+
Aozeal Certified Standards (AOCS), Inc.
M0005.00
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI24849936
+
H&Z Industry Co.,Ltd
HIC7202880
+
Shandong SanYoung Industry Co., Ltd
SSI12605040
+
Inke S.A.
IS324972
Guangzhou Topwork Chemical Co., Ltd.
GTC12965184
+
Suan Farma, Inc
SFI5402160
+
Arcadia Biotechnology
AB7562268
+
Hangzhou Verychem Science & Technology Co., Ltd.
HVST17288640
+
Xiamen Equation Chemical Co.,Ltd
XECC11525760
+
Sancai Industry Co.,Ltd.
SIC8643456
+
Aecochem Corp.
AC5041512
+
CSNpharm, Inc.
CSN11455
Hangzhou Keying Chem Co., Ltd.
HKC10804320
+
Hangzhou Lingrui Chemical Co., Ltd.
HLC12605040
+
Wanko Chemical Co., Ltd.
WC8642592
Sigma-Aldrich International GmbH
SI11523456
+
Carbone Scientific Co., Ltd.
CS10083024
+
Pharmacore Co., Limited
PL8282484
Hefei Hirisun Pharmatech Co., Ltd
HR010575
+
CM Fine Chemicals
CFC6122448
AK Scientific, Inc.
AS6842052
+
Xingrui Industry Co., Limited
XIL10444176
+
Leap Chem Co., Ltd
LC6481944
+
Santa Cruz Biotechnology, Inc.
202231
Dayang Chem (Hangzhou) Co.,Ltd.
DC11164464
+
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CAS equal suppliers

Montelukast (Acid)
Aozeal Certified Standards (AOCS), Inc.
M0005.01
Montelukast sodium salt
BOC Sciences
BS8282484
Montelukast Sodium Hydrate
TCI Chemicals (India) Pvt. Ltd.
M2340
Sodium (R,E)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate
BLD Pharmatech Ltd
BP59616178848
sodium (R,S)-2-(1-(((1-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-(2-(2-hydroxypropan-2-yl)phenyl)propyl)thio)methyl)cyclopropyl)acetate
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC425306
Sodium-2-[1-[[(1R)-1-[3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl]-3-[2-(1-hydroxy-1-methyl-ethyl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetate
Manchester Organics Limited
F47777

Prices & Availability




Data is processed


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Properties for Montelukast Sodium

Molecular Weight:
608.17 g·mol−1
Melting point:
135.5° C
Boiling point:
750.5° C at 760 mmHg (Predicted)
Solubility:
Soluble in ethanol (100 mM), DMSO (100 mM), methanol, water (>100 mg/ml at 25° C), and DMF (~30 mg/ml).
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Hazard Statements

GHS05

GHS05
Corrosive
  • Corrosive to metals, category 1
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R41 - Risk of serious damage to eyes
R62 - Possible risk of impaired fertility
R63 - Possible risk of harm to the unborn child
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
-20°C Freezer, Under Inert Atmosphere
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Alternative Distributors of [Montelukast Sodium]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Matrix Laboratories Limited | Changsha Huajia Chemical Science Co., Ltd. | Sai Ram Organics Private Limited | CNCCC Sichuan Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Pharmasi Chemicals Co., Ltd. | Zhejiang Materials Industry Chemical Group Co., Ltd. | Synfine Research Inc. | Chemwill Asia Co.,Limited | China Risesun Group Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | TCS INDUSTRY LTD. | Lanospharma Laboratories Co., Ltd. | Rosewell Industry Co., Ltd. | Jinan Great Chemical Co., Ltd. | Nantong Qihai Chemicals Co., Ltd. | Zouping Mingxing Chemical Co., Ltd. | Bichem Lab Co., Ltd. | Jinjiangchem Corporation | ShangHai Biochempartner Co., Ltd. | 3Way Pharm Inc. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | API Vanguard | Orex Pharma Pvt. Ltd | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Cfm Oskar Tropitzsch GmbH | Yongyi Chemicals Group Co., Ltd. | Beijing Yangguang Furuide Chemical Co., Ltd. | Watson International Ltd | Aopharm | BOC Sciences | Mei Le Shi Limited | Jinan Haohua Industry Co., Ltd. | Trademax Phamaceuticals & Chemicals Co., Ltd. | Clearsynth Canada INC. | Wanko Chemical Co., Ltd. | Haihang Industry Co., Ltd.

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