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5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB)

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Formula: C16H16N2O4
CAS: 107254-86-4

Identification

Structural Formula
5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB)
CAS:
107254-86-4
EINECS:
Molecular Formula:
C16H16N2O4
MDL:
MFCD00153851
SMILES:
C1=CC=C(C=C1)CCCNC2=C(C=C(C=C2)[N+](=O)[O-])C(=O)O
Synonym:
5-nitro-2-(3-phenylpropylamino)benzoic acid, 5-nitro-2-[(3-phenylpropyl)amino]benzoic acid, benzoic acid ; c13705 ; compound 144 ; 3-nitro-6-[(3-phenylpropyl)amino]benzoic acid ; nppb ; 5-nitro-2-(3-phenylpropylamino)-benzoic acid 98% ; 5-nitro-2-(3-phenylpropylamino)benzoic a cid potent chloride chann ; 5-nitro-2-(3'-phenylpropyl-amino)benzoic acid ; 5-nitro-2-(3-phenylpropylamino)benzoic acid,nppb ; 5-nitro-2-(3-phenylpropylamino)benzoic acid


Description

5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB) is a potent Cl- channel blocker, identified through an optimization study of the diphenylamine-2-carboxylate core which demonstrates the basic Cl- channel blocking activity. NPPB also demonstrates suppression of prostaglandin E2 release with an IC50 of 8 μM, presumed to be a Cox (cyclooxygenase) inhibitor given its structural similarity to fenamic acid-type Cox inhibitors. It is also a GPR35 activator.


Suppliers

Santa Cruz Biotechnology, Inc.
201542
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Properties for 5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB)

Molecular Weight:
300.31 g·mol−1
Density:
1.32 g/cm3
Melting point:
180-182° C
Boiling point:
~523.47° C at 760 mmHg (Predicted)
Solubility:
ethanol: 3 mg/mL
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Safety & Transport Information

Storage temperature :
-20°C
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Alternative Distributors of [5-Nitro-2-(3-phenylpropylamino)benzoic Acid (NPPB)]

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