Pam3Cys-Ser-(Lys)4 trihydrochloride | CAS 112208-00-1

Element: trihydrochloride pam3cys

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C-S » Chemicals » pam-cys-ser-lys-trihydrochloride-PX74023

Identification

Pam3Cys-Ser-(Lys)4 trihydrochloride

CAS:

112208-00-1

EINECS:

Molecular Formula:

C₈₁H₁₅₆N₁₀O₁₃S

MDL:

SMILES:

CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O.Cl.Cl.Cl

Synonym:

pam3cys-ser-lys-lys-lys-lys-oh, pam3csk4 ; pam3csk4 ; sine ; pam3cys-skkkk ; pam3-cys-ser-lys-lys-lys-lys-oh ; n-palmitoyl-s-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-ly ; palmitoyl-cys((rs)-2,3-di(palmitoyloxy)-propyl)-ser-lys-lys-lys-lys-oh ; pam3cyssk4 ; p 3c ; pam3cys-ser-(lys)4 . 3hcl

Description

Pam₃Cys-Ser-(Lys)₄ trihydrochloride, sometimes derived from N-terminus of bacterial lipoproteins, has been shown to be a potent activator of Balb/c splenocytes in vitro and an agonist of TLR1/TLR2 (Toll-like receptor 1 and 2 complex). In murine bone marrow studies, this compound has displayed a cytotoxic capacity. Additionally, Pam₃Cys-Ser-(Lys)₄ trihydrochloride has been reported to activate O₂ formation and lysozyme release in neutrophils. This agent has also been noted to be a very potent adjuvant in murine models.