PKG Inhibitor | CAS 82801-73-8 | Chemical-Suppliers

Element: inhibitor

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C-S » Chemicals » pkg-inhibitor-PX80406

Identification

PKG Inhibitor

CAS:

82801-73-8

EINECS:

Molecular Formula:

C₃₈H₇₄N₁₈O₁₀

MDL:

MFCD00080098

SMILES:

C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)N

Synonym:

rkrarke ; cgmp dependent kinase inhibitor peptide ; arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid ; cgmp-dependent protein kinase inhibitor peptide ; [ala32]-histone h2b (29-35) ; l-glutamicacid, n-[n2-[n2-[n-[n2-(n2-l-arginyl-l-lysyl)-l-arginyl]-l-alanyl]-l-arginyl]-l-lysyl]- ; 7: pn: us20070122395 page: 23unclaimed sequence ; l-glutamic acid,l-arginyl-l-lysyl-l-arginyl-l-alanyl-l-arginyl-l-lysyl- ; protein kinase g inhibitor ; h-arg-lys-arg-ala-arg-lys-glu-oh ; arg-lys-arg-ala-arg-lys-glu ; l-glutamic acid, n-(n2-(n2-(n-(n2-(n2-l-arginyl-l-lysyl)-l-arginyl)-l-alanyl)-l-arginyl)-l-lysyl)- ; alg-lys-arg-ala-arg-lys-glu ; pkg inhibitor ; 6: pn: us20090092566 seqid: 6 claimed protein ; arg-7-glu

Description

PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. NMDA potentiation and GABA nitric oxide depression have been reported to be blocked by the PKG inhibitor. Other PKG inhibitors include KT5823, which activates apoptotic DNA fragmentation.