Z-Prolyl-prolinal | CAS 86925-97-5

Element: prolinal prolyl

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C-S » Chemicals » prolyl-prolinal-PX75437

Identification

Z-Prolyl-prolinal

CAS:

86925-97-5

EINECS:

Molecular Formula:

C₁₈H₂₂N₂O₄

MDL:

MFCD11975334

SMILES:

C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)OCC3=CC=CC=C3)C=O

Synonym:

z-pp-cho ; z-prolyl-prolinal ; z-prolyl-prolinal (z-pro-pro-cho) ; prolyl endopeptidase inhibitor ii ; 1-pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (s-(r*,r*))- ; n-benzyloxycarbonylprolylprolinal ; z-pro-pro-cho ; z-pro-prolinal

Description

Z-Prolyl-prolinal (Z-PP-CHO) is a potent and specific, cell-permeable dipeptide aldehyde inhibitor of PREP (prolyl endopeptidase) (K_i = 350 pM and 500 pM for mouse brain and human brain, respectively). Z-PP-CHO has also been shown to inhibit the cleavage of arginine-vasopressin (ARG-Vasopressin), gonadotropin-releasing hormone (GnRH I), and other peptides. It has been reported that Z-Pro-prolinal is a putative transition-state analogue for prolyl oligopeptidase, and forms a tetrahedral complex with the enzyme at the active serine.

Suppliers

Santa Cruz Biotechnology, Inc.

201285

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Prices & Availability

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Properties for Z-Prolyl-prolinal

Molecular Weight:

330.38 g·mol−1

Density:

1.31 g/cm³

Melting point:

191.31° C

Boiling point:

529.08° C at 760 mmHg

Solubility:

Soluble in DMSO (≥10 mg/mL ).

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Alternative Distributors of [Z-Prolyl-prolinal]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

-/-

MSDS:

-/-