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Pyrimethamine

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Formula: C12H13ClN4
CAS: 58-14-0
search Element: pyrimethamine
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Identification

Structural Formula
Pyrimethamine
CAS:
58-14-0
EINECS:
200-364-2
Molecular Formula:
C12H13ClN4
MDL:
MFCD00057350
SMILES:
CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl
Synonym:
wr2978 ; bw50-63 ; malacid ; malocid ; nsc3061 ; rp 4753 ; wr 2978 ; 4753r.p. ; bw 50-63 ; daraclor


Description

Pyrimethamine is a potent inhibitor of multi-drug and toxin extrusion transporters. This compound inhibits Mdr-1(P-glycoprotein) and thus allows for active drugs to stay within the cell for longer periods of time, increasing their effectiveness by preventing efflux of the active compound from the cytoplasm. Pyrimethamine also inhibits DHFR(dihydrofolate reductase ).


Suppliers

Shandong SanYoung Industry Co., Ltd
SSI4551820
+
Chemlyte Solutions
CS234702
+
Autech Industry Co.,Limited
AIC3511404
+
Ambeed, Inc.
A195764
+
Pharmore Ingredients, Inc.
PI3381014
IBIS Chemie International
ICI3251300
+
Junwee Chemical Co., Ltd.
JC325975
+
Xiamen Equation Chemical Co.,Ltd
XECC4162080
+
CSNpharm, Inc.
CSN12806
Hangzhou Keying Chem Co., Ltd.
HKC3901560
+
Sigma-Aldrich International GmbH
SI4161248
+
Carbone Scientific Co., Ltd.
CS3641092
+
AK Scientific, Inc.
AS247741
+
Xingrui Industry Co., Limited
XIL3771508
+
Capot Chemical Co., Ltd.
9611
+
Leap Chem Co., Ltd
LC234702
+
Santa Cruz Biotechnology, Inc.
208190
Dayang Chem (Hangzhou) Co.,Ltd.
DC4031612
+
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Prices & Availability




Data is processed


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Properties for Pyrimethamine

Molecular Weight:
248.71 g·mol−1
Density:
~1.4 g/cm3 (Predicted)
Melting point:
233-234°C
Boiling point:
368.4° C at 760 mmHg
Solubility:
Soluble in Ethanol (hot)
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Hazard Classes:
6.1(b)
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
0-6°C
RID/ADR certification :
3249
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Alternative Distributors of [Pyrimethamine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | BOC Sciences | Inter-Chemical Ltd. | Share Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | Chang Shu League Chemical Co. Ltd. | Watson International Ltd | Santec Chemicals Corp. | Hallochem Pharma Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | Pharmasi Chemicals Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | Taizhou Creating Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Shenzhen Xing Jia Feng Since and Technology Development Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | Clearsynth Canada INC. | Suzhou Rovathin Pharmatech Co., Ltd | Unispec Chemicals Co. | Haihang Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | East Chemical Industry Co., Ltd.

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