SKI II | CAS 312636-16-1 | Chemical-Suppliers

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C-S » Chemicals » ski-PX65317

Identification

SKI II

CAS:

312636-16-1

EINECS:

Molecular Formula:

C₁₅H₁₁ClN₂OS

MDL:

MFCD00733553

SMILES:

C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl

Synonym:

ski ii (sphk-i2) ; sphk-i2 ; 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]phenol ski ii ; sphingosine kinase inhibitor 2 ; phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]- ; 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol ; sphingosine kinase inhibitor ; ski ii (sphingosine kinase inhibitor)

Description

SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC₅₀ = 0.5 µM); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. SKI II induces apoptosis and inhibits prpliferation in several other tumor cell lines in vitro (IC₅₀ = 0.9-4.6 μM).

Suppliers

Ambeed, Inc.

A122860

Aea.ltd

A84168

CSNpharm, Inc.

CSN18688

Santa Cruz Biotechnology, Inc.

204286

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CAS equal suppliers

SKI-II, 98%

Alfa (A Johnson Matthey Company)

A3521056

Ski ii (sphk-i2)

ABCR GmbH & Co. KG

AB479899

Sphingosine Kinase Inhibitor 2

AK Scientific, Inc.

AS17105130

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Leap Chem Co., Ltd

LC592217766

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

Finipharma Ltd

F46069212

Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]-

Angene International Limited

AGN-PC-0JVXKW

Prices & Availability

Data is processed

Properties for SKI II

Molecular Weight:

302.784 g·mol−1

Density:

1.42 g/cm³ (Predicted)

Melting point:

191.70° C (Predicted)

Boiling point:

507.06° C at 760 mmHg (Predicted)

Solubility:

DMSO: ≥20 mg/mL

Safety & Transport Information

Storage temperature :

2-8°C

Alternative Distributors of [SKI II]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | D&P Global Chemical Co., Ltd

Downloads

Mol File:

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MSDS:

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