N-Stearoyl-glycine

N-Stearoyl-glycine has been used in the study of bioactive N-acyl amides, a novel family of putative endogenous signaling lipids with multiple effects on pain, inflammation, and other biological systems. The effect of N-Stearoyl-glycine on primary sensory neurons has been studied, and single cell calcium imaging revealed a significant level of calcium influx, but still markedly lower than N-palmitoyl glycine. Recent studies have shown endogenous levels of N-Stearoyl-glycine are found in skin. N-Acyl glycines can be efficiently degraded by FAAH. FAAH is a microsomal enzyme involved in the hydrolysis of several bioactive amides and esters and can regulate in vivo levels of N-stearoyl glycine.