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Tamoxifen Citrate

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Formula: C26H29NO.C6H8O7
CAS: 54965-24-1
search Element: tamoxifen citrate
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Identification

Structural Formula
Tamoxifen Citrate
CAS:
54965-24-1
EINECS:
259-415-2
Molecular Formula:
C26H29NO.C6H8O7
MDL:
MFCD00058321
SMILES:
CC/C(=C(C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
Synonym:
txndc ; adopan ; tmx1 ; terimon ; tmx ; kessar ; noltam ; txndc1 ; tamofen ; zemide


Description

Tamoxifen Citrate is a potent and selective inhibitor of PKC (protein kinase C). It is known that Tamoxifen Citrate functions in PKC ε translocation. Studies suggest that Tamoxifen Citrate functions as an estrogen receptor antagonist in breast tissue. Once bound to the estrogen receptor Tamoxifen Citrate will not allow any other ligand to bind to the receptor. In contrast, Tamoxifen Citrate is an agonist towards this receptor in tissues of the endometrium. Studies indicate Tamoxifen Citrate inhibits DNA synthesis and transcription by recruiting co-repressors, which stop estrogen from interacting with genes. When combined with PAX2, Tamoxifen Citrate can inhibit the proliferation of ERBB2. It is also a high affinity activator of the GPR30 receptor. Tamoxifen Citrate is an activator of Estrogen Receptor.


Suppliers

H&Z Industry Co.,Ltd
HIC6802720
+
Aozeal Certified Standards (AOCS), Inc.
T0074.00
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI23469384
+
Shandong Lanhai Industry Co.,Ltd.
SLIC11225610
+
Aea.ltd
A238476
+
EXCELLA GmbH
E408816
Chemische Fabrik Berg GmbH
CFB8843536
AXO Industry SA
AIS5102040
+
Alfa (A Johnson Matthey Company)
A10883264
BoomKing Industrial Co.,Limited
BIC10544216
+
Sancai Industry Co.,Ltd.
SIC8163264
+
Aecochem Corp.
AC4761428
+
Hangzhou Keying Chem Co., Ltd.
HKC10204080
+
Wanko Chemical Co., Ltd.
WC8162448
Sigma-Aldrich International GmbH
SI10883264
+
scienTEST - bioKEMIX GmbH
S-B8503400
+
Finetech Industry Limited
FIL8503400
+
AK Scientific, Inc.
AS6461938
+
Xingrui Industry Co., Limited
XIL9863944
+
BOC Sciences
BS4081224
+
Amadis Chemical Company Limited
ACCL10545270
+
Leap Chem Co., Ltd
LC6121836
+
Santa Cruz Biotechnology, Inc.
203288
Dayang Chem (Hangzhou) Co.,Ltd.
DC10544216
+
Get Quick Quote

CAS equal suppliers

Tamoxifene citrate
Simagchem Corporation
SC7562268
Tamoxifen citrate, 98%
Acros Organics BVBA
AOB8363344

Prices & Availability




Data is processed


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Properties for Tamoxifen Citrate

Molecular Weight:
563.64 g·mol−1
Melting point:
140-144 °C
Boiling point:
482.3° C at 760 mmHg (Predicted)
Solubility:
Soluble in methanol (50 mg/ml with heat) or ethanol (10 mg/ml with sonication); very slightly soluble in water (0.3 mg/L @ 20°C; the pH is approximately 3.0-3.5), 0.02 N HCl (0.2 mg/ml @ 37°C)4, acetone ,chloroform,and DMSO(100mM)
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
R45 - May cause cancer
R60 - May impair fertility
R61 - May cause harm to the unborn child
R64 - May cause harm to breast-fed babies
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Classes:
irritant
Hazard Symbols:
T, Xi
Hazard symbol T Hazard symbol Xi
Storage temperature :
2-8°C
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Alternative Distributors of [Tamoxifen Citrate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Santec Chemicals Corp. | Molekula GmbH | CCS. CHEM. Co., Ltd. | Shanghai Zhongyitai International Trading Co., Ltd. | Afine Chemicals Limited | Xiang Ding Chemical International Co., Ltd | Nantong Chem-Tech. (Group) Co., Ltd. | TCI Europe NV | China Yangzhou Wandong Medical Co., Ltd. | Zibo Panxin Pharmaceutical Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Chemsors chemicals Co., Ltd. | Lanospharma Laboratories Co., Ltd. | TCS INDUSTRY LTD. | Jinan Great Chemical Co., Ltd. | Yangzhou Siyu Chemical Co., Ltd. | Bichem Lab Co., Ltd. | Hangzhou Holypharm Biotech Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Discovery Fine Chemicals Limited | Watson International Ltd | Beijing Yangguang Furuide Chemical Co., Ltd. | Shanghai Arbor Chemical Co., Ltd. | BOC Sciences | Suzhou Bichal Biological Technology Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Clearsynth Canada INC. | Wanko Chemical Co., Ltd. | Zhuhai Jiacheng Bio-Tech Co., Ltd. | Haihang Industry Co., Ltd.

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