TAPI-0 | CAS 143457-40-3 | Chemical-Suppliers

Element: tapi

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C-S » Chemicals » tapi-PX63535

Identification

TAPI-0

CAS:

143457-40-3

EINECS:

Molecular Formula:

C₂₄H₃₂N₄O₅

MDL:

MFCD02684279

SMILES:

CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)N

Synonym:

Description

TAPI-0 (TNF-α Protease Inhibitor-0) is a hydroxamate-based inhibitor of MMP (collagenase, gelatinase) and TACE (TNF-α converting enzyme/ADAM17; IC₅₀ = 100 nM). TAPI-0 blocks spontaneous and PMA-induced release of TNF α in transfected COS 7 cells. TAPI-0 is an inhibitor of Meprin A α.