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TGF-β RI Kinase Inhibitor V

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Formula: C17H10ClFN6
CAS: 627536-09-8
search Element: inhibitor kinase beta

Identification

Structural Formula
TGF-β RI Kinase Inhibitor V
CAS:
627536-09-8
EINECS:
Molecular Formula:
C17H10ClFN6
MDL:
MFCD11519969
SMILES:
C1=CC(=C(C=C1Cl)C2=NC3=NC=CN=C3C(=N2)NC4=CC=NC=C4)F
Synonym:
4-pteridinamine, 2-(5-chloro-2-fluorophenyl)-n-4-pyridinyl- ; 2-(5-chloro-2-fluorophenyl)-n-4-pyridinyl-4-pteridinamine ; 2-(5-chloro-2-fluorophenyl)-n-(pyridin-4-yl)pteridin-4-amine ; sci 208 ; 2-[(5-chloro-2-fluorophenyl)pteridin-4-yl]pyridin-4-yl-amine ; sd-208 ; 2-(5-chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine ; tgf-β ri kinase inhibitor v ; 2-(5-chloro-2-fluorophenyl)-n-4-pyridinyl-


Description

TGF-β RI Kinase Inhibitor V is a selective and reversible inhibitor, which suppresses TGF-β RI/ALK5 signaling. It is known that TGF-β RI Kinase Inhibitor V also inhibits p38α at concentrations greater than 867 nM. Studies indicate that TGF-βRI Kinase Inhibitor V reduces the number of myofibroblasts at fibroblastic foci. In addition, this compound is effective in blocking autocrine and paracrine TGF-β signaling in glioma cells and restores the lytic activity of polyclonal natural killer cells against glioma cells. This inhibitor functions in suppressing the action of MAPKAP and PKD.


Suppliers

Santa Cruz Biotechnology, Inc.
203294
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TGF-beta RI Kinase Inhibitor V
Santa Cruz Biotechnology, Inc.
sc-203294
4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-n-4-pyridinyl-
Angene International Limited
AGN-PC-0N2FJK

Prices & Availability




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Properties for TGF-β RI Kinase Inhibitor V

Molecular Weight:
352.7529032 g·mol−1
Density:
1.487
Melting point:
214.79° C (Predicted)
Boiling point:
460.41° C at 760 mmHg (Predicted)
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [TGF-β RI Kinase Inhibitor V]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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