Thalidomide | CAS 50-35-1 | Chemical-Suppliers

Element: thalidomide

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C-S » Chemicals » thalidomide-PX71722

Identification

Thalidomide

CAS:

50-35-1

EINECS:

200-031-1

Molecular Formula:

C₁₃H₁₀N₂O₄

MDL:

MFCD00153873

SMILES:

C1CC(=O)NC(=O)C1N2C(=O)C3=CC=CC=C3C2=O

Synonym:

nibrol ; pangul ; k 17 ; neo ; glupan ; e-217 ; sedin ; myrin ; k17 ; isomin

Description

Thalidomide was commonly used therapeutically in the late 1950’s, however, it was withdrawn from the market when it was discovered to cause birth defects. More recent research has found Thalidomide to affect key biochemical pathways yielding antiangiogenic and immunomodulatory activities. This compound has been shown to: selectively inhibit TNF α (tumor necrosis factor-α) biosynthesis and basic fibroblast growth factor (bFGF)-induced angiogenesis, induce apoptosis in human monocytes via a cytochrome c-dependent pathway, and to inhibit HIV-1 replication in a monocytoid (U1) line. These new found uses make Thalidomide an extremely valuable research tool.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Shandong Ench Chemical Co.,Ltd

SECC3301650

Shandong SanYoung Industry Co., Ltd

SSI3851540

Ambeed, Inc.

A164079

Aozeal Certified Standards (AOCS), Inc.

T0021.00

Alfa (A Johnson Matthey Company)

A3521056

Quzhou Rundong Chemical Co., Ltd.

QRC3631452

CSNpharm, Inc.

CSN12073

Carbone Scientific Co., Ltd.

CS308924

AK Scientific, Inc.

AS209627

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

201445

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

(+/-)-Thalidomide

TCI Chemicals (India) Pvt. Ltd.

T2524

(+/-)-Thalidomide

ABCR GmbH & Co. KG

AB347541

Thalidomide Impurity

Pharmaffiliates Analytics & Synthetics Pvt. Limited

PA 43 55610

(+/-)-Thalidomide, 99+%

Alfa (A Johnson Matthey Company)

A14724416

Lenalidomide Impurity 21

Aozeal Certified Standards (AOCS), Inc.

L0024.29

Thalidomide - Labeled d4

Santa Cruz Biotechnology, Inc.

sc-356134

2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione

Hangzhou MolCore BioPharmatech Co.,Ltd.

CS12019

2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

BLD Pharmatech Ltd

BP680420412

Prices & Availability

Data is processed

Properties for Thalidomide

Molecular Weight:

258.23 g·mol−1

Density:

1.50 g/cm³

Melting point:

269-271°C

Boiling point:

509.75° C at 760 mmHg

Solubility:

45% (w/v) aq 2-hydroxypropyl-Î²-cyclodextrin: 0.6 mg/mL

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

GHS08
Health hazard

Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A, 1B, 2
Carcinogenicity, categories 1A, 1B, 2
Reproductive toxicity, categories 1A, 1B, 2
Specific target organ toxicity following single exposure, categories 1, 2
Specific target organ toxicity following repeated exposure, categories 1, 2
Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:

R21 - Harmful in contact with skin
R22 - Harmful if swallowed
R25 - Toxic if swallowed
R46 - May cause inheritable genetic damage
R61 - May cause harm to the unborn child
R62 - Possible risk of impaired fertility

Safety Codes:

S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use

Hazard Classes:

6.1(b)

Hazard Symbols:

Storage temperature :

Store at RT

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Thalidomide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified