Potent inhibitor of bacterial and yeast RNA polymerases. Inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III); inhibits mannan and glucan formation in Saccharomyces cerevisiae; used for the analysis of mRNA stability; inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and suppresses tumor cell-induced angiogenesis in vivo. Publications: Kebaara BW, Nielsen LE, Nickerson KW, Atkin AL.; Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor. Genome 2006; 49(8): 894-9. Minamiguchi K, Kumagai H, Masuda T, Kawada M, Ishizuka M, Takeuchi T.; Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis. Int J Cancer 2001; 93(3): 307-16. Sturdikova M, Proksa B, Uhrin D, Fuska J.; Regulation of biosynthesis of thiolutin and aureothricin in Streptomyces kasugaensis. Folia Microbiol (Praha) 1990; 35(4): 278-83. Bergmann R.; Thiolutin inhibits utilization of glucose and other carbon sources in cells of Escherichia coli.; Antonie Van Leeuwenhoek 1989; 55(2): 143-52. Jimenez A, Tipper DJ, Davies J.; Thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Mode of action.; Antimicrob Agents Chemother 1973; 3(6): 729-38. Tipper DJ.; Thiolutin inhibits yeast ribonucleic acid polymerases; J Bacteriol 1973; 116(1): 245-56.
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