Thiostrepton | CAS 1393-48-2 | Chemical-Suppliers

Element: thiostrepton

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C-S » Chemicals » thiostrepton-PX79324

Identification

Thiostrepton

CAS:

1393-48-2

EINECS:

215-734-9

Molecular Formula:

C₇₂H₈₅N₁₉O₁₈S₅

MDL:

MFCD00135828

SMILES:

CCC(C)[C@@H]1N[C@@H]2C=CC3=C(N=C(C=C3[C@H](C)O)C(=O)O[C@H](C)[C@@H]3NC(=O)C4=CSC(=N4)[C@@H](NC(=O)[C@H]4CSC(=N4)C(NC(=O)[C@@H](NC(=O)C4=CSC(=N4)[C@]4(CCC(=N[C@H]4C4=CSC3=N4)C3=NC(=CS3)C(=O)NC(=C)C(=O)NC(=C)C(N)=O)NC(=O)[C@H](C)NC(=O)C(=C)NC(=O)[C@H](C)NC1=O)[C@@H](C)O)=C/C)[C@@](C)(O)[C@@H](C)O)[C@H]2O

Synonym:

thiostreption ; bryamycin ; thiactin ; thiostrepton (200 mg) ; thiostrepton ; x146 ; antibiotica8506 ; antibioticx146 ; a-8506 ; antibiotic6761-31

Description

Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1.

Suppliers

H&Z Industry Co.,Ltd

HIC240960

Leap Chem Co., Ltd

LC216648

Santa Cruz Biotechnology, Inc.

203412

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

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CAS equal suppliers

Thiostreptonfromstreptomycesazureus

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HJC10854340

thiostrepton from streptomyces azureus

Indofine Chemical Co, Inc.

Bio-968

Prices & Availability

Data is processed

Properties for Thiostrepton

Molecular Weight:

1664.89 g·mol−1

Density:

1.64 g/cm³ (Predicted)

Melting point:

248-257 °C (dec.)

Solubility:

Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water.

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Hazard Symbols:

Storage temperature :

-20°C

Alternative Distributors of [Thiostrepton]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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