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TPEN

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Formula: C26H28N6
CAS: 16858-02-9
search Element: tpen

Identification

Structural Formula
TPEN
CAS:
16858-02-9
EINECS:
Molecular Formula:
C26H28N6
MDL:
MFCD00036918
SMILES:
C1=CC=NC(=C1)CN(CCN(CC2=CC=CC=N2)CC3=CC=CC=N3)CC4=CC=CC=N4
Synonym:
1,2-ethanediamine,n,n,n',n'-tetrakis(2-pyridinylmethyl)- ; n,n,nntetrakis-pyridin-2-ylmethyl-ethane-1,2-diamine ; n,n,n',n'-tetrakis(pyridin-2-yl-methyl)ethylenediamine ; pyridine,2,2',2'',2'''-[ethylenebis(nitrilodimethylene)]tetra- (8ci) ; tpen, >=98% ; n,n,nntetrakis(2-pyridylmethyl)-1,2-ethylenediamine ; tpeda ; n,n,n',n'-tetrakis(2-pyridylmethyl)-1,2-ethanediamine ; tetrakis-(2-pyridylmethyl)ethylenediamine ; tpen/ch63857 ; tpen ; n,n'-ethylenebis[bis(2-pyridyl)amine] ; n,n,n',n'-tetrakis(2-pyridylmethyl)ethylenediamine ; n,n,n',n'-tetra(2-pyridyl)-1,2-ethanediamine ; n,n,n',n',-tetrakis(2-pyridylmethyl)*eth ylenediamin


Description

TPEN is a cell permeable, high-affinity heavy metal (Zn2+>Fe2+>Mn2+) chelator that exhibits low affinity for Mg2+ and Ca2+. The compound is lipid-soluble and has been shown to permeate artificial and natural membranes. Research shows that TPEN induces apoptosis in human and rat thymocytes through DNA fragmentation and Caspace-3 activation. TPEN also induces mitochondrial cytochrome C translocation to the cytosol in human PBL. A recent study has proved this chelator to work in conjunction with the fluorescent probe Fura-2 in biophysical studies of Ca2+.


Suppliers

Aea.ltd
A2856
CSNpharm, Inc.
CSN12120
Zehao Industry Co., Ltd.
ZI96288
Santa Cruz Biotechnology, Inc.
200131
Dayang Chem (Hangzhou) Co.,Ltd.
DC124496
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CAS equal suppliers

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
TCI Chemicals (India) Pvt. Ltd.
T1487
N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
Gihi Chemicals Co., Limited
GCL810032400
N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
Zehao Industry Co., Ltd.
ZI720021600
N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
Alfa (A Johnson Matthey Company)
A979229376

Prices & Availability




Data is processed


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Properties for TPEN

Molecular Weight:
424.5407 g·mol−1
Density:
1.186 g/cm3
Melting point:
110-112 °C
Boiling point:
542.1 °C at 760 mmHg
Flash point:
281.7 °C
Solubility:
Soluble in DMSO(100 mg/10 ml-clear, colorless solution); slightly soluble in water
Physical Description:
colourless crystals
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
Refrigerator
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Alternative Distributors of [TPEN]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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