Vatalanib Dihydrochloride | CAS 212141-51-0

Element: dihydrochloride vatalanib

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C-S » Chemicals » vatalanib-dihydrochloride-PX63760

Identification

Vatalanib Dihydrochloride

CAS:

212141-51-0

EINECS:

Molecular Formula:

C₂₀H₁₅ClN₄.2HCl

MDL:

MFCD08458964

SMILES:

C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl

Synonym:

Description

Vandetanib Dihydrochloride inhibits VEGFR-dependent tumor angiogenesis and EGFR- and RET-dependent tumor cell proliferation and survival. Vatalanib Dihydrochloride also inhibits Flk, c-Kit and PDGFR-β with IC₅₀ of 270 nM, 730 nM and 580 nM, respectively. Furthermore, Vatalanib Dihydrochloride shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs

Suppliers

Ambeed, Inc.

A392716

Finetech Industry Limited

FIL12505000

Xingrui Industry Co., Limited

XIL14505800

Leap Chem Co., Ltd

LC9002700

Santa Cruz Biotechnology, Inc.

202379

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CAS equal suppliers

Vatalanib

Aea.ltd

A63126

Vatalanib 2HCl

Excenen Pharmatech Co., Ltd.

EX-A334

Vatalanib 2HCl

CSNpharm, Inc.

CSN12454

Prices & Availability

Data is processed

Properties for Vatalanib Dihydrochloride

Molecular Weight:

419.73 g·mol−1

Melting point:

244-246° C

Solubility:

Soluble in DMSO (30 mg/mL), ethanol (10 mg/mL) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also soluble in methanol, and water ( ≥10 mg/mL ).

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Alternative Distributors of [Vatalanib Dihydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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