R-Venlafaxine | CAS 93413-46-8 | Chemical-Suppliers

Element: venlafaxine

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C-S » Chemicals » venlafaxine-PX75211

Identification

R-Venlafaxine

CAS:

93413-46-8

EINECS:

Molecular Formula:

C₁₇H₂₇ N O₂

MDL:

MFCD07369692

SMILES:

COC1=CC=C(C=C1)[C@H](CN(C)C)C1(O)CCCCC1

Synonym:

cyclohexanol,1-[(1r)-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]- ; (+)-venlafaxine ; venlafaxine r-isomer ; r-venlafaxine ; cyclohexanol,1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]-, (r)- ; (r)-(+)-venlafaxine

Description

R-Venlafaxine is an optically active version of Venlafaxine. Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine; 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake. In vitro studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or α-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4.