Zileuton | CAS 111406-87-2 | Chemical-Suppliers

Element: zileuton

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C-S » Chemicals » zileuton-PX73483

Identification

Zileuton

CAS:

111406-87-2

EINECS:

Molecular Formula:

C₁₁H₁₂N₂O₂S

MDL:

MFCD00866097

SMILES:

CC(C1=CC2=CC=CC=C2S1)N(C(=O)N)O

Synonym:

leutml ; abt-077 ; zyfl ; a-64077 ; leutrol ; griluto-cr ; akos 91253 ; zileuton ; cgs-23622 ; zyflo

Description

Zileuton is an orally active 5-LO (5-lipoxygenase) inhibitor that inhibits LTB4 synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Zileuton inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and shows antiasthmatic activity in vivo. Zileuton also weakly inhibits CYP1A2 (K_i = 66 - 98 μM).

Suppliers

Aozeal Certified Standards (AOCS), Inc.

Z0011.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI5522208

European Technologies Inc.

ET208624

CSNpharm, Inc.

CSN12237

Finetech Industry Limited

FIL200800

Carbone Scientific Co., Ltd.

CS224672

Hefei Hirisun Pharmatech Co., Ltd

HR011918

AK Scientific, Inc.

AS152456

Simagchem Corporation

SC168504

Capot Chemical Co., Ltd.

14804

Amadis Chemical Company Limited

ACCL2481240

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

204417

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CAS equal suppliers

ZILEUTON USP

Corey Organics PVT Limited

COPL6243120

Urea, n-(1-benzo[b]thien-2-ylethyl)-n-hydroxy-

Angene International Limited

AGN-PC-07A28M

1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea

BLD Pharmatech Ltd

BP777623328

Prices & Availability

Data is processed

Properties for Zileuton

Molecular Weight:

236.29 g·mol−1

Density:

~1.4 g/cm³ (Predicted)

Melting point:

157-158 °C

Boiling point:

~449.4° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (47 mg/ml at 25° C), methanol, ethanol (47 mg/ml at 25° C), DMF (~30 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (~0.5 mg/ml).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36 - Irritating to eyes

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

Store at +4 °C

Alternative Distributors of [Zileuton]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

-/-

MSDS:

-/-

Related products

View related products

Zileuton Related Compound A

Zileuton-Beta-D-Glucuronide

Zileuton-d4

Zileuton-13C2,15N

Zileuton Impurity 2

Zileuton ß-D-Glucuronide

Zileuton Related compound C

Zileuton-β-D-Glucuronide