6α-Prostaglandin I1 | CAS 62777-90-6

Element: prostaglandin alpha

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C-S » Chemicals » alpha-prostaglandin-PX64164

Identification

6α-Prostaglandin I1

CAS:

62777-90-6

EINECS:

Molecular Formula:

C₂₀H₃₄O₅

MDL:

SMILES:

CCCCCC(O)/C=C/[C@H]1C(O)CC2O[C@H](CCCCC(=O)O)CC12

Synonym:

6r,9alpha-epoxy-11alpha,15s-dihydroxy-prost-13e-en-1-oic acid ; 6α-prostaglandin i1 ; (6r,13e,15s)-6,9α-epoxy-11α,15-dihydroxyprost-13-en-1-oic acid ; 6alpha-prostaglandin i1 ; 5,6alpha-dihydro pgi2

Description

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response. 6α-PGI1 exhibits an IC₅₀ of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).