ATM/ATR Kinase Inhibitor | CAS 905973-89-9

Element: inhibitor kinase

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » atm-atr-kinase-inhibitor-PX68190

Identification

ATM/ATR Kinase Inhibitor

CAS:

905973-89-9

EINECS:

Molecular Formula:

C₂₃H₁₈Cl₃FN₄O₃S

MDL:

MFCD09038682

SMILES:

C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

Synonym:

benzeneacetamide, a-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxometh yl]amino]ethyl]- ; a-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide ; cgk733 ; α-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide ; 2,2-diphenyl-n-(2,2,2-trichloro-1-[3-(4-fluoro-3-nitrophenyl)thioureido]ethyl)acetamide ; 905973-89-9 ; alpha-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide ; atm/atr kinase inhibitor ; alpha-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide cgk 733 ; cgk 733, >=98% ; benzeneacetamide, α-phenyl-n-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-

Description

ATM/ATR Kinase Inhibitor (CGK733) was originially published as a cell permeable compound that selectively inhibits the kinase activity of ATM and ATR at an IC₅₀ ~ 200 nM without significant effect against other PIKK family members DNA-PK, mTOR and PI 3-kinase (PI3K) or kinases that are known to phosphorylate p53 (ERK, Cytokeratin 1(CAK), Cdk2, JNK, PKC, cyclin H(CAK), Chk1, PKR, and p38). The claims of this product is retracted and the effect of the ATM/ATR Kinase Inhibitor (CGK733) have not been fully investigated.