Tpl2 Kinase Inhibitor

Tpl2 Kinase Inhibitor is a reversible naphthyridine ATP-competitive inhibitor of the enzyme Cot (Tpl2 kinase). The enzyme is a hematopoietically expressed serine-threonine kinase responsible for regulating tumor necrosis factor-α, toll-like receptor, and G protein–coupled receptor signaling. Studies suggest that Cot (Tpl2 kinase) inhibitor suppresses LPS-induced TNF-α production from primary human monocytes. In addition, Tpl2 kinase inhibitor causes an increase in 1,25-Dihydroxyvitamin D3 (1,25D)-induced differentiation of myeloid leukemia cells via inhibition of Cot (Tpl2 kinase).