Flt-3 Inhibitor | CAS 301305-73-7

Element: inhibitor

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Identification

Flt-3 Inhibitor

CAS:

301305-73-7

EINECS:

Molecular Formula:

C₁₈H₂₀ N₂ O₄ S

MDL:

MFCD00617269

SMILES:

COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

Synonym:

2-(3,4-dimethoxybenzamido)- 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide ; flt-3 inhibitor ; 2-(3,4-dimethoxy-benzoylamino)-4,5,6,7-t ; benzo[b]thiophene-3-carboxamide,2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro- ; 2-(3,4-dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide ; 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxamide ; flt-3 inhibitor ; 2-(3,4-dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide ; 2-[(3,4-dimethoxybenzoyl)amino]-4,5,6,7-benzo[b]thiophene-3-carboxamide ; tcs359

Description

Flt-3 Inhibitor is a cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3/Flk-2 (Flt-3) inhibitor (IC₅₀ = 42 nM) with little effect against a panel of 22 other kinases (IC₅₀ ≥3 μM).

Suppliers

Santa Cruz Biotechnology, Inc.

203048

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Prices & Availability

Data is processed

Properties for Flt-3 Inhibitor

Molecular Weight:

360.432 g·mol−1

Density:

1.328 g/cm3

Melting point:

257.34° C (Predicted)

Boiling point:

454.4°C at 760 mmHg

Flash point:

228.6°C

Solubility:

Soluble in water (<2 mg/ml), DMSO (15 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used