12(S)-HEPE | CAS 116180-17-7 | Chemical-Suppliers

Element: hepe

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C-S » Chemicals » hepe-PX72025

Identification

12(S)-HEPE

CAS:

116180-17-7

EINECS:

Molecular Formula:

C₂₀H₃₀ O₃

MDL:

Synonym:

5,8,10,14,17-eicosapentaenoicacid, 12-hydroxy-, [s-(e,z,z,z,z)]- ; 12s-hydroxy-5z,8z,10e,14z,17z-eicosapentaenoic acid ; 12(s)-hepe ; 12-hepe ; 5,8,10,14,17-eicosapentaenoicacid, 12-hydroxy-, (5z,8z,10e,12s,14z,17z)-

Description

12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the antiinflammatory potential of ω-3 fatty acids.