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PTP Inhibitor II

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Formula: C9H9BrO2
CAS: 2632-13-5
search Element: inhibitor
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Identification

Structural Formula
PTP Inhibitor II
CAS:
2632-13-5
EINECS:
220-118-8
Molecular Formula:
C9H9BrO2
MDL:
MFCD00000201
SMILES:
COC1=CC=C(C=C1)C(=O)CBr
Synonym:
2-bromo-4-methoxy ; ptp inhibitor ii ; 4-methoxyphenacyl bromide ; timtec-bb sbb007777 ; 4-(bromoacetyl)anisole ; p-methoxyphenacyl bromide ; 2-bromo-4'-methoxyac ; 4-methoxy phenecyl bromide ; akos bbs-00000817 ; 4-methoxyphenacyl br


Description

PTP inhibitor II is a cell-permeable, covalent and potent PTP (protein tyrosine phosphatase) inhibitor. The compound acts by binding the catalytic domain of the SH2 domain-containing phosphatase SHP-1(DSH2). PTP inhibitor II binds with lower affinity than PTP Inhibitor I (Ki = 128 μM and Ki = 43 μM respectively). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. PTP inhibitors have demonstrated enhanced clonogenic survival, mutagenesis and cell growth. PTP inhibitors can also be useful for probing signal transduction pathways as well as drugs for treatment of PTP-related diseases. PTP Inhibitor II is an inhibitor of PTP1B and SH-PTP1.


Suppliers

CSNpharm, Inc.
CSN20785
Santa Cruz Biotechnology, Inc.
202784
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Prices & Availability




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Properties for PTP Inhibitor II

Molecular Weight:
229.07 g·mol−1
Density:
1.45 g/cm3 (Predicted)
Melting point:
69-71 °C(lit.)
Boiling point:
285° C
Solubility:
Soluble in DMSO, water (partly miscible), most organic solvents, and methanol.
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Hazard Statements

GHS05

GHS05
Corrosive
  • Corrosive to metals, category 1
GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R34 - Causes burns
R36/37 - Irritating to eyes and respiratory system
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S27 - Take off immediately all contaminated clothing
S28 - After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S37/39 - Wear suitable gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
8
Hazard Symbols:
C, Xi
Hazard symbol C Hazard symbol Xi
Storage temperature :
2-8°C
RID/ADR certification :
UN 3261 8 / PG 2
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Alternative Distributors of [PTP Inhibitor II]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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