Wee1 Inhibitor | CAS 622855-37-2

Element: inhibitor wee1

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C-S » Chemicals » wee-inhibitor-PX84598

Identification

Wee1 Inhibitor

CAS:

622855-37-2

EINECS:

Molecular Formula:

C₂₀H₁₁ClN₂O₃

MDL:

SMILES:

C1=CC=C(C(=C1)C2=CC3=C(C4=C(N3)C=CC(=C4)O)C5=C2C(=O)NC5=O)Cl

Synonym:

Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy-

Description

Wee1 Inhibitor is a pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC₅₀ = 11 nM) in an ATP-competitive manner and displays ~40-fold selectivity over the related checkpoint kinase Chk1 (IC₅₀ = 440 nM).