(±)17,18-DiHETE | CAS 116477-53-3

Element: dihete plusmn

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C-S » Chemicals » dihete-PX61309

Identification

(±)17,18-DiHETE

CAS:

116477-53-3

EINECS:

Molecular Formula:

C₂₀H₃₂O₄

MDL:

SMILES:

CC[C@H]([C@H](C/C=CC/C=CC/C=CC/C=CCCCC(=O)O)O)O

Synonym:

Description

Eicosapentaenoic acid (EPA) is an ω-3 fatty acid in marine organisms. 17,18-DiHETE is a major metabolite produced when EPA is incubated with various rat tissue homogenates or cynomolgus monkey seminal vesicles. The route of production of 17,18-DiHETE likely proceeds through cytochrome P450-catalyzed epoxidation at the ω-3 double bond followed by conversion to the vicinal diols by epoxide hydrolase. EPA is metabolized preferentially by Gaeumannomyces graminis to 17,18-DiHETE.