5(S),12(S)-DiHETE | CAS 73151-67-4

Element: dihete

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Identification

5(S),12(S)-DiHETE

CAS:

73151-67-4

EINECS:

Molecular Formula:

C₂₀H₃₂O₄

MDL:

SMILES:

CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O

Synonym:

6e-12-epi-leukotriene b4 ; (5s,12s,6e,8e,10e,14z)-5,12-dihydroxy-6,8,10,14-icosatetraenoic acid ; (5s,6e,8e,10e,12s,14z)-5,12-dihydroxy-6,8,10,14-icosatetraenoic acid ; 6-trans-12-epi leukotriene b4 ; 5(s), 12(s)-dihete ; (5s,12s)-dihydroxy-(6e,8e,10e,14z)-*eicosatetraen ; (5s,12s)-dihydroxy-(6e,8e,10e,14z)-eicos atetraenoi ; 6-trans-12-epi-ltb4 ; 5(s),12(s)-dihydroxyeicosa-6e,8e,10e,14z-tetraenoic acid ; (5s,12s)-dihydroxy-(6e,8e,10e,14z)-eicosatetraenoic acid

Description

Leukotrienes comprise a family of endogenous metabolites of certain fatty acids and are related to thromboxanes and prostaglandins. They are potent eicosanoid lipid mediators that play numerous roles in inflammation, immunological functions and maintaining biological homeostasis. Leukotrienes possess a conjugated triene structure which gives them their name. They are generally isolated from leukocytes and primarily act through specific G protein-coupled receptors. 5(S),12(S)-DiHETE (6-trans-12-epi-LTB4) is synthesized via nonenzymatic hydrolysis of LTA4 and by myeloperoxidase-dependent metabolism of cysteinyl leukotrienes. See 5-Lipoxygenase Pathway for structure

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Santa Cruz Biotechnology, Inc.

200426

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Data is processed

Properties for 5(S),12(S)-DiHETE

Molecular Weight:

336.47 g·mol−1

Density:

0.79 g/cm³ at 20° C

Boiling point:

78° C at 760 mmHg

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
S7 - Keep container tightly closed

Hazard Symbols:

F, Xi